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Revista Medica Del Instituto Mexicano... Jan 2023After the first successful blood transfusion, different difficulties of a liquid tissue were overcome; this liquid required special conditions to keep its... (Review)
Review
After the first successful blood transfusion, different difficulties of a liquid tissue were overcome; this liquid required special conditions to keep its characteristics with minimal alterations and, thus, to be able to be used in patients who needed it. Subsequently, techniques that also made possible to separate this liquid into its different components for its use were discovered, allowing a more specific treatment of the deficiencies of patients when administering cellular or non-cellular elements. With this, a new area arose within the blood banks to obtaining components. This area became the central point of convergence of all the processes involved in obtaining components, which include the biological qualification of each one of the units, as well as their labeling and release for the different distribution in transfusion services. It is important to highlight that the main source of components is obtained from whole blood; its processing for several decades was an artisanal operator-dependent process; however, with the evolution of technology, now it is possible to carry it out in an automated manner; likewise, today it is possible to obtain components directly from the donor's whole blood by separating it in real time by means of apheresis, which allows obtaining the component of interest and returning the remainder to the donor.
Topics: Humans; Blood Banks; Blood Component Transfusion; Blood Transfusion; Blood Donors; Blood Component Removal
PubMed: 36378143
DOI: No ID Found -
Blood Transfusion = Trasfusione Del... Mar 2021The COVID-19 pandemic is placing blood and tissue establishments under unprecedented stress, putting its capacity to provide the adequate care needed at risk. Here we...
BACKGROUND
The COVID-19 pandemic is placing blood and tissue establishments under unprecedented stress, putting its capacity to provide the adequate care needed at risk. Here we reflect on how our integrated organisational model has faced the first impact of the pandemic and describe what challenges, opportunities and lessons have emerged.
MATERIALS AND METHODS
The organisational model of the Catalan Blood and Tissue Bank (Banc de Sang i Teixits, BST) is described. The new scenario was managed by following international recommendations and considering the pandemic in a context of volatility, uncertainty, complexity, and ambiguity (VUCA), allowing rapid measures to be taken. These aimed to: ensure donor safety, promote proper responses to patients' needs, ensure the health and well-being of personnel, and prepare for future scenarios.
RESULTS
The BST has adapted its activities to the changes in demand. No shortage of any product or service occurred. Donor acceptance, safety and wellbeing were maintained except for tissue donation, which almost completely stopped. To support the health system, several activities have been promoted: large-scale convalescent plasma (CP) production, clinical trials with CP and mesenchymal stromal cells, massive COVID-19 diagnoses, and participation in co-operative research and publications. Haemovigilance is running smoothly and no adverse effects have been detected among donors or patients.
DISCUSSION
Several elements have proven to be critical when addressing the pandemic scenario: a) the early creation of a crisis committee in combination with technical recommendations and the recognition of a VUCA scenario; b) identification of the strategies described; c) the integrated donor-to-patient organisational model; d) active Research and Development (R&D); and e) the flexibility of the staff. It is essential to underline the importance of the need for centralised management, effective contingency strategies, and early collaboration with peers.
Topics: Blood Banks; Blood Component Transfusion; Blood Donors; Bone Marrow Transplantation; COVID-19; Humans; Immunization, Passive; Models, Organizational; Occupational Diseases; Pandemics; SARS-CoV-2; Safety; Spain; Tissue Banks; Tissue and Organ Procurement; COVID-19 Serotherapy
PubMed: 33539280
DOI: 10.2450/2021.0259-20 -
BMJ (Clinical Research Ed.) Jan 1992
Topics: Blood Banks; Bone Transplantation; Humans; Tissue Banks; United Kingdom
PubMed: 1737140
DOI: 10.1136/bmj.304.6819.68 -
Blood Transfusion = Trasfusione Del... Jul 2011Umbilical cord blood (CB) banking and therapeutic use raise several ethical issues: medical indications, legal framework, public versus private biobanks, autologous... (Comparative Study)
Comparative Study Review
BACKGROUND AND OBJECTIVES
Umbilical cord blood (CB) banking and therapeutic use raise several ethical issues: medical indications, legal framework, public versus private biobanks, autologous versus allogeneic use, ownership, commercialisation, quality assurance and many others. Surrogate informed consent is one of the most notable controversial ethical issues. The aim of this study was to analyse and compare informed consent forms for CB collection, storage and use in the 18 accredited biobanks of the Italian Network.
MATERIAL AND METHODS
The first part of the article gives a brief overview of the scientific framework, the comparison of allogeneic and autologous use and Italian regulations. In the second part the contents of the consent forms from the 18 Italian biobanks are compared with the "NetCord-FACT International Standards for Cord Blood Collection, Banking, and Release for Administration".
RESULTS
Most of the Italian consent forms differ significantly from the NetCord-FACT Standards, with regards both to formal and substantial aspects.
CONCLUSION
Italian forms for CB collection, storage and use need standardisation to meet international criteria.
Topics: Bioethical Issues; Blood Banks; Blood Donors; Blood Preservation; Consent Forms; Fetal Blood; Humans; Italy; Blood Banking
PubMed: 21251456
DOI: 10.2450/2010.0083-10 -
Current Oncology (Toronto, Ont.) Dec 2022The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups. An...
BACKGROUND
The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups. An analysis of distributed units is needed to assess the effectiveness of the bank to meet the needs of patients from different ethnic groups.
METHODS
A descriptive analysis was performed on all cord blood units distributed from the CBS' CBB as of 30 June 2022.
RESULTS
Distribution of the first 60 units based on CBS' CBB inventory has been linear over time. A similar proportion of cord blood unit (CBU) recipients were pediatric or adult. More than half of the cord blood units (56.7%) were distributed to recipients outside of Canada, and CBUs were used to treat a broad range of hematologic and immune disorders. 43.3% of distributed CBUs were of non-Caucasian ethnicity and 18% were from donors self-reporting as multi-ethnic. The mean total nucleated cell counts and total CD34 cell counts were 1.9 ± 0.1 × 10 cells and 5.3 ± 0.5 × 10 CD34 cells, respectively. CD34 cells per kg (recipient weight) varied significantly between pediatric (age 0-4), adolescent (age 5-17) and adult recipients (age 18 and older) (3.1 ± 0.5, 1.4 ± 0.5 and 0.9 ± 0.07 × 10 CD34 cells/kg, respectively). HLA matching was 6/6 (15%), 5/6 (47%) or 4/6 (38%).
CONCLUSIONS
The CBS' CBB has facilitated the utilization of banked units for patients across a broad range of ages, geographic distribution, ethnicity, and diseases. Distributed units were well matched for HLA alleles and contained robust cell counts, reflecting a high-quality inventory with significant utility.
Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Blood Banks; Canada; Fetal Blood; HLA Antigens; Alleles; Cord Blood Stem Cell Transplantation
PubMed: 36547166
DOI: 10.3390/curroncol29120752 -
Sultan Qaboos University Medical Journal Feb 2018Sickle cell disease and homozygous β-thalassaemia are common haemoglobinopathies in Oman, with many implications for local healthcare services. The transfusions of such... (Review)
Review
Sickle cell disease and homozygous β-thalassaemia are common haemoglobinopathies in Oman, with many implications for local healthcare services. The transfusions of such patients take place in many hospitals throughout the country. Indications for blood transfusions require local recommendations and guidelines to ensure standardised levels of care. This article summarises existing transfusion guidelines for this group of patients and provides recommendations for blood banks and transfusion services in Oman. This information is especially pertinent to medical professionals and policy-makers developing required services for the standardised transfusion support of these patients.
Topics: Anemia, Sickle Cell; Blood Banks; Blood Transfusion; Hemoglobinopathies; Humans; Oman; Review Literature as Topic; beta-Thalassemia
PubMed: 29666675
DOI: 10.18295/squmj.2018.18.01.002 -
Canadian Journal of Gastroenterology &... 2022Hepatitis B is a severe, widespread infectious disease of the liver that affects millions of people around the world. It is one of the life-threatening liver infections...
BACKGROUND
Hepatitis B is a severe, widespread infectious disease of the liver that affects millions of people around the world. It is one of the life-threatening liver infections caused by the hepatitis B virus (HBV). HBV is the cause of up to 80% of cases of primary liver cancer. Due to the potential risk associated with HBV infection, it is important to study the factors which are associated with the seropositive volunteers.
OBJECTIVE
The purpose of this study was to identify factors associated with seropositivity for the hepatitis B virus among volunteers who donated blood at the Jimma Blood Bank in southern Ethiopia.
METHODS
Cross-sectional research was conducted on blood donors who came to the Jimma Blood Bank to donate their blood. Three hundred and fifty-nine volunteer blood donors who arrived at the Jimma Blood Bank were investigated face-to-face in order to collect sociodemographic characteristics and risk factors for HBV infection. The data were analyzed using statistical software SPSS version 20.0. The association between the risk factor for HBV infection and HBV infection was determined using chi-square tests.
RESULT
In total, there were 359 participants; their mean age was 22.5, among which 161 (44.8%) were males. Out of 359 volunteers, 13 (3.6%) were seropositive for HBsAg. The test positivity rate among males was 7/198 (3.54%), while the rate among females was 6/161 (3.7%). More than 3/4 of those who tested positive were under the age of 40. Chi-square analysis showed that volunteers whose income was between 12 and 26.84 USD were less likely to have the infectious disease than those whose income was less than 11.84 USD per month (=0.042).
CONCLUSION
The prevalence of HBV was found to be 3.6% among selected volunteers. It was found that, out of 20 volunteers, 13 had infection. Chi-square analysis showed that HBV infection was associated with low monthly income and the use of unsafe therapeutic injections.
Topics: Adult; Blood Banks; Blood Donors; Cross-Sectional Studies; Ethiopia; Female; Hepatitis B; Hepatitis B virus; Humans; Male; Prevalence; Volunteers; Young Adult
PubMed: 35655943
DOI: 10.1155/2022/7458747 -
The New England Journal of Medicine Jan 1997
Topics: Adult; Blood Banks; Child; Disclosure; Fetal Blood; Hematopoietic Stem Cell Transplantation; Humans; Infant, Newborn; Nontherapeutic Human Experimentation; Parental Consent; Patient Advocacy; Patient Selection; Placenta; Resource Allocation; Risk Assessment; Therapeutic Human Experimentation
PubMed: 8984336
DOI: 10.1056/NEJM199701023360114 -
Anesthesiology Apr 2008
Topics: Anesthesiology; Blood Banks; Color; Humans; Plasma
PubMed: 18362615
DOI: 10.1097/ALN.0b013e3181672668 -
Blood Jun 1993Numerous independent and interdependent factors are involved in the posttransfusion platelet response. Factors such as ABO match and platelet age are related to...
Numerous independent and interdependent factors are involved in the posttransfusion platelet response. Factors such as ABO match and platelet age are related to circumstances potentially under the control of the blood bank physician and therefore may permit circumvention by an active transfusion service. On the other hand, factors such as fever or sepsis may be unavoidable, being related more to the individual patient or clinical condition. To evaluate which factors could be circumvented, we prospectively followed the 1-hour corrected count increments (CCIs) for 962 single-donor apheresis platelet transfusions to 71 refractory hematologic oncology inpatients, with concomitant recording of implicated factors. Stepwise regression analysis allowed for determination of which concurrent and confounding clinical-, patient-, and blood bank-related factors significantly affected the CCIs. Although many implicated factors proved to be independently associated with an increased or decreased CCI, we found that no single variable consistently explained the CCI variation across the patient population. Each patient appeared sensitive to one or a few particular factors, but because of marked intraindividual variation, it was not possible to identify a priori which factors were important for a given patient. The single exception was a solid-phase red blood cell adherence assay used to cross-match platelets, but only for alloimmunized patients. We also evaluated the utility of requesting HLA-matched platelets from the local suppliers and maintained a clear distinction between platelets simply ordered as HLA matched and actually HLA-identical platelets. Accounting for the confounding clinical-, patient-, and blood bank-related factors, the cross-match assay was a better predictor of an adequate CCI than ordering platelets as HLA matched.
Topics: Blood Banks; Blood Component Transfusion; Blood Grouping and Crossmatching; Blood Platelets; Hematologic Diseases; Histocompatibility Testing; Humans; Immunization; Isoantigens; Platelet Count; Prospective Studies; Regression Analysis
PubMed: 8507878
DOI: No ID Found